Across TCGA patient cohorts, HMGB1P17 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,459 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P17-associated GO terms across cancer lineages are Tolerance induction, Negative regulation of leukocyte apoptotic process, and Negative regulation of cell activation. Each is linked with HMGB1P17 in more than 20 cancer types. Because this analysis shows association rather than direction, both HMGB1P17-to-partner and partner-to-HMGB1P17 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P17→partner) and Y-score (partner→HMGB1P17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Tolerance induction →	+0.071	+0.136	<.001	<.001	3	21
STAD	Negative regulation of leukocyte apoptotic process →	+0.062	+0.128	<.001	<.001	3	21
STAD	Negative regulation of cell activation →	+0.051	+0.140	<.001	<.001	3	21
STAD	Negative regulation of innate immune response →	+0.053	+0.146	<.001	<.001	3	21
BRCA	T cell tolerance induction →	+0.083	+0.148	<.001	<.001	3	20
SKCM	Regulation of tolerance induction →	+0.080	+0.249	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,459 associations by consensus.

Exploration

HMGB1P17 survival (RNA) · tumor vs normal (RNA) · all HMGB1P17 data types