Across TCGA patient cohorts, HMGB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,265 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGB1-associated proteins across cancer lineages are NASP, PDS5B, and CHAMP1. Each is linked with HMGB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HMGB1-to-partner and partner-to-HMGB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1→partner) and Y-score (partner→HMGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NASP →	+0.421	+0.437	.001	.001	3	6
GBM	PDS5B →	+0.299	+0.415	<.001	<.001	3	6
HNSC	CHAMP1 →	+0.342	+0.646	<.001	<.001	3	6
UCEC	RNASEH2C →	+0.389	+0.544	<.001	<.001	3	5
LSCC	SMC2 →	+0.467	+0.503	<.001	<.001	3	5
LSCC	TIMELESS_S1173 →	+0.930	+0.605	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,265 associations by consensus.

Exploration

HMGB1 survival (RNA) · tumor vs normal (RNA) · all HMGB1 data types