Across TCGA patient cohorts, HMGB1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,934 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGB1-associated genes across cancer lineages are PAN3, PDS5B, and POLR1D. Each is linked with HMGB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB1-to-partner and partner-to-HMGB1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1→partner) and Y-score (partner→HMGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAN3 →	+0.728	+0.425	<.001	<.001	3	9
LSCC	PDS5B →	+0.555	+0.291	<.001	<.001	3	8
COAD	POLR1D →	+0.483	+0.429	<.001	<.001	3	7
LSCC	TUBGCP3 →	+0.545	+0.256	.001	.006	3	7
HNSC	RNASEH2B →	+0.508	+0.317	<.001	<.001	3	7
HNSC	USPL1 →	+0.764	+0.398	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,934 associations by consensus.

Exploration

HMGB1 survival (RNA) · tumor vs normal (RNA) · all HMGB1 data types