Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, HMGB1 mutation is significantly associated with the RNA expression of many other genes, with 2,463 significant associations in total. UCEC shows the largest number of these associations.
The most reproducible HMGB1-associated genes across cancer lineages are FANCB, CDCA2, and CENPP. Each is linked with HMGB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB1-to-partner and partner-to-HMGB1 results are reported.
Each partner links to its own Q-omics profile.
mutation associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (HMGB1→partner) and Y-score (partner→HMGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.