Across TCGA patient cohorts, HMGB1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and YB-1. Each is linked with HMGB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB1-to-partner and partner-to-HMGB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1→partner) and Y-score (partner→HMGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.217	+2.351	.029	.018	3	2
UCEC	Cyclin-B1 →	+0.522	+2.584	.011	.010	3	2
SARC	YB-1 →	+0.263	+2.833	.024	.034	3	1
UCEC	14-3-3_beta →	-0.082	-3.295	.026	.009	3	1
UCEC	eEF2 →	+0.339	+1.502	.009	.030	3	1
UCEC	EGFR_pY1068 →	-0.235	-2.000	.010	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

HMGB1 survival (RNA) · tumor vs normal (RNA) · all HMGB1 data types