Across TCGA cell cohorts, HMGB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,728 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HMGB1-associated GO terms across cancer lineages are DNA-templated DNA replication, Positive regulation of metaphase/anaphase transition of cell cycle, and Mitotic sister chromatid cohesion. Each is linked with HMGB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both HMGB1-to-partner and partner-to-HMGB1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1→partner) and Y-score (partner→HMGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated DNA replication →	+0.167	+1.368	<.001	<.001	3	20
URINARY_TRACT	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.203	+1.064	<.001	<.001	3	19
BONE	Mitotic sister chromatid cohesion →	+0.143	+1.252	<.001	<.001	3	19
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.138	+1.256	.001	.003	3	18
OESOPHAGUS	Protein localization to kinetochore →	+0.191	+1.177	.002	<.001	3	18
URINARY_TRACT	Positive regulation of mitotic metaphase/anaphase transition →	+0.195	+1.034	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,728 associations by consensus.

Exploration

HMGB1 survival (RNA) · tumor vs normal (RNA) · all HMGB1 data types