HMGA2

Across TCGA patient cohorts, HMGA2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,623 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HMGA2-associated genes across cancer lineages are RPSAP52, HMGA2-AS1, and IGF2BP2. Each is linked with HMGA2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HMGA2-to-partner and partner-to-HMGA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGA2 versus RPSAP52 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA2→partner) and Y-score (partner→HMGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPSAP52 →	+1.487	+1.339	<.001	<.001	3	8
UCEC	HMGA2-AS1 →	+1.599	+0.968	<.001	<.001	3	7
GBM	IGF2BP2 →	+1.912	+1.341	<.001	.001	3	7
UCEC	IGF2BP2-AS1 →	+1.660	+1.293	<.001	<.001	3	6
GBM	DKK1 →	+2.717	+1.173	.002	.002	3	5
HNSC	PLAG1 →	+1.069	+0.824	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,623 associations by consensus.

HMGA2 vs RPSAP52 — UCEC

Explore this scatter interactively →