HMGA1

Across TCGA pan-cancer cohorts, HMGA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HMGA1 data layer compared with 31 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HMGA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HMGA1 expression acts as an unfavorable survival marker, although some lineages such as OV and CCRCC show a favorable association.

PDAC, OV, and HNSC are the cancer types where HMGA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.327	0.653	.002	41	view →
OV	DFS	Quartile	All	0.922	0.431	.010	16	view →
HNSC	DFS	Median	All	0.698	1.000	.020	10	view →
CCRCC	DFS	Quartile	All	0.910	0.628	.013	3	view →
LUAD	OS	Quartile	II,III,IV	0.619	0.313	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HMGA1–PDAC (OS)

Open the PDAC breakdown →