HMGA1

Across TCGA pan-cancer cohorts, HMGA1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of HMGA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HMGA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGA1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LUAD, COAD, and KIRP are the cancer types where HMGA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+2.591	<.001	11	view →
COAD	All	III,IV	+1.751	<.001	11	view →
KIRP	All	III,IV	+1.682	<.001	11	view →
STAD	All	II,III,IV	+2.105	<.001	10	view →
LUSC	Male	III,IV	+3.147	<.001	9	view →
LIHC	Male	II,III,IV	+2.771	<.001	9	view →
KIRC	All	II,III,IV	−0.724	<.001	9	view →
BLCA	Male	III,IV	+3.338	<.001	8	view →
THCA	Male	III,IV	+1.565	<.001	8	view →
HNSC	Male	All	+1.488	<.001	8	view →
UCEC	All	All	+2.116	<.001	6	view →
BRCA	All	III,IV	+1.194	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

HMGA1–LUAD

Open the LUAD breakdown →