HMGA1

Across TCGA patient cohorts, HMGA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,426 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGA1-associated proteins across cancer lineages are CRYL1, HMGA1_T53, and SMC2. Each is linked with HMGA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGA1-to-partner and partner-to-HMGA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGA1 versus CRYL1 in OV, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA1→partner) and Y-score (partner→HMGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRYL1 →	-0.443	-0.844	<.001	<.001	3	9
OV	HMGA1_T53 →	+1.052	+1.038	<.001	<.001	3	9
UCEC	SMC2 →	+0.611	+1.059	<.001	<.001	3	9
OV	HMGA1_S44 →	+1.317	+1.219	.001	.002	2	9
LUAD	MKI67_S357 →	+1.186	+0.921	<.001	<.001	3	8
OV	NAA50 →	+0.339	+0.905	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,426 associations by consensus.

HMGA1 vs CRYL1 — OV

Explore this scatter interactively →