HMGA1

Across TCGA patient cohorts, HMGA1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,673 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGA1-associated genes across cancer lineages are PLAG1, PNMA2, and CSNK2B. Each is linked with HMGA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HMGA1-to-partner and partner-to-HMGA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGA1 versus PLAG1 in UCEC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA1→partner) and Y-score (partner→HMGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLAG1 →	+1.191	+0.602	<.001	<.001	3	7
CCRCC	PNMA2 →	-0.680	-0.272	.008	.005	3	4
HNSC	CSNK2B →	+0.644	+0.380	<.001	<.001	3	4
UCEC	IGF2BP2-AS1 →	+1.491	+0.600	<.001	<.001	3	4
UCEC	MIR497HG →	-0.488	-0.468	<.001	<.001	3	4
UCEC	IGF2BP2 →	+1.849	+0.724	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,673 associations by consensus.

HMGA1 vs PLAG1 — UCEC

Explore this scatter interactively →