HMGA1

Across TCGA patient cohorts, HMGA1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGA1-associated genes across cancer lineages are p70-S6K, Rictor_pT1135, and eEF2. Each is linked with HMGA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGA1-to-partner and partner-to-HMGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by HMGA1-low versus HMGA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA1→partner) and Y-score (partner→HMGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.237	+3.196	.025	.010	3	1
UCEC	Rictor_pT1135 →	-0.123	-3.169	.028	.020	3	1
UCEC	eEF2 →	+0.409	+3.169	.037	.020	2	1
UCEC	Cyclin-B1 →	+0.804	+3.169	.009	.020	2	1
UCEC	p62 Lck ligand →	+0.622	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p70-S6K by HMGA1 expression — UCEC

Explore this box plot interactively →