HMGA1

Across TCGA cell cohorts, HMGA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HMGA1-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Tubulin deacetylation, and rRNA metabolic process. Each is linked with HMGA1 in more than 10 cancer types. Because this analysis shows association rather than direction, both HMGA1-to-partner and partner-to-HMGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by HMGA1-low versus HMGA1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGA1→partner) and Y-score (partner→HMGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Maturation of SSU-rRNA →	+0.132	+1.736	<.001	<.001	3	11
OVARY	Tubulin deacetylation →	-0.113	-1.216	.001	.008	3	11
LUNG_SCLC	rRNA metabolic process →	+0.121	+1.666	<.001	.001	3	10
LUNG_SCLC	rRNA processing →	+0.117	+1.600	.001	.001	3	10
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.105	+1.137	<.001	<.001	3	10
BLOOD_Lymphoma	Transcription by RNA polymerase III →	+0.076	+1.377	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Maturation of SSU-rRNA by HMGA1 expression — LUNG_SCLC

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