HMG20B

Across TCGA pan-cancer cohorts, HMG20B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HMG20B data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HMG20B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HMG20B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where HMG20B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.931	0.681	.002	23	view →
UCEC	DFS	Tertile	II,III,IV	0.620	1.000	.024	16	view →
PDAC	DFS	Median	All	0.327	0.496	.010	14	view →
CCRCC	DFS	Median	II,III,IV	0.451	1.000	.008	12	view →
HNSC	DFS	Tertile	All	0.543	0.740	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HMG20B–LSCC (OS)

Open the LSCC breakdown →