HMG20B

Across TCGA patient cohorts, HMG20B mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMG20B-associated genes across cancer lineages are ATM, Caspase-8, and p62 Lck ligand. Each is linked with HMG20B in more than 1 cancer types. Because this analysis shows association rather than direction, both HMG20B-to-partner and partner-to-HMG20B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HMG20B-low versus HMG20B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMG20B→partner) and Y-score (partner→HMG20B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.467	-2.459	.033	.020	3	1
UCEC	Caspase-8 →	-0.246	-3.169	.042	.019	3	1
UCEC	p62 Lck ligand →	+0.532	+3.584	<.001	.002	1	1
UCEC	Annexin-1 →	+0.767	+3.584	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by HMG20B expression — UCEC

Explore this box plot interactively →