HMG20A

Across TCGA pan-cancer cohorts, HMG20A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HMG20A data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HMG20A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMG20A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where HMG20A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.234	0.895	<.001	27	view →
CCRCC	DFS	Tertile	All	0.979	0.514	.015	13	view →
GBM	DFS	Quartile	All	0.441	0.264	.013	8	view →
LUAD	OS	Median	All	0.911	0.765	.019	7	view →
PDAC	DFS	Tertile	IV	0.777	0.217	.024	5	view →
LSCC	OS	Quartile	All	0.948	0.669	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HMG20A–HNSC (DFS)

Open the HNSC breakdown →