HMG20A

Across TCGA pan-cancer cohorts, HMG20A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HMG20A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMG20A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMG20A is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, STAD, and THCA are the cancer types where HMG20A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMG20A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.607	<.001	11	view →
STAD	Male	II,III,IV	+0.848	<.001	6	view →
THCA	All	II,III,IV	−0.588	.006	5	view →
BLCA	All	III,IV	+0.485	.013	4	view →
CHOL	All	All	+1.326	<.001	3	view →
LUAD	Female	II,III,IV	−0.502	.002	3	view →
LIHC	All	All	+0.478	.002	3	view →
UCEC	All	All	−0.575	.025	2	view →
KIRP	Female	II,III,IV	+0.516	.046	2	view →
KICH	All	All	−0.396	.007	2	view →
PRAD	All	All	−0.321	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HMG20A–HNSC

Open the HNSC breakdown →