HMG20A

Across TCGA patient cohorts, HMG20A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMG20A-associated genes across cancer lineages are Paxillin, 14-3-3_beta, and eEF2. Each is linked with HMG20A in more than 1 cancer types. Because this analysis shows association rather than direction, both HMG20A-to-partner and partner-to-HMG20A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Paxillin grouped by HMG20A-low versus HMG20A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMG20A→partner) and Y-score (partner→HMG20A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Paxillin →	+0.299	+2.594	.002	.006	3	2
UCEC	14-3-3_beta →	-0.121	-1.752	.001	.014	3	1
UCEC	eEF2 →	+0.341	+1.765	.011	.014	3	1
UCEC	EGFR_pY1068 →	-0.291	-2.807	.002	.002	3	1
UCEC	eIF4G →	+0.321	+3.459	.005	.005	3	1
UCEC	FASN →	+0.302	+1.415	.041	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Paxillin by HMG20A expression — UCEC

Explore this box plot interactively →