HMCN1

Across TCGA patient cohorts, HMCN1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,196 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMCN1-associated genes across cancer lineages are RBMS3, CCN2, and SEPTIN4. Each is linked with HMCN1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMCN1-to-partner and partner-to-HMCN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMCN1 versus RBMS3 in BRCA, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCN1→partner) and Y-score (partner→HMCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBMS3 →	+0.962	+0.834	<.001	<.001	3	9
OV	CCN2 →	+2.239	+1.181	<.001	<.001	3	9
PDAC	SEPTIN4 →	+0.562	+0.451	<.001	<.001	3	8
PDAC	PPFIA2 →	+0.849	+0.517	<.001	<.001	3	8
OV	ADAMTS10 →	+1.093	+0.644	<.001	<.001	3	8
UCEC	CORIN →	+1.104	+0.545	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,196 associations by consensus.

HMCN1 vs RBMS3 — BRCA

Explore this scatter interactively →