Across TCGA patient cohorts, HMCES RNA expression is significantly associated with the protein abundance of many other proteins, with 11,969 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMCES-associated proteins across cancer lineages are GMPS, RFC4, and MCM2. Each is linked with HMCES in more than 8 cancer types. Because this analysis shows association rather than direction, both HMCES-to-partner and partner-to-HMCES results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCES→partner) and Y-score (partner→HMCES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GMPS →	+0.935	+0.781	<.001	<.001	3	8
BRCA	RFC4 →	+0.413	+0.420	<.001	<.001	3	8
LUAD	MCM2 →	+0.698	+0.409	<.001	<.001	3	8
OV	MCM3 →	+0.751	+0.607	<.001	<.001	2	9
OV	MCM4 →	+0.737	+0.714	<.001	<.001	3	8
OV	MCM5 →	+0.664	+0.752	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,969 associations by consensus.

Exploration

HMCES survival (RNA) · tumor vs normal (RNA) · all HMCES data types