Across TCGA patient cohorts, HMCES protein abundance is significantly associated with the RNA expression of many other genes, with 14,991 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMCES-associated genes across cancer lineages are TOPBP1, UMPS, and CCDC58. Each is linked with HMCES in more than 8 cancer types. Because this analysis shows association rather than direction, both HMCES-to-partner and partner-to-HMCES results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMCES→partner) and Y-score (partner→HMCES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOPBP1 →	+0.969	+0.626	<.001	<.001	3	9
LSCC	UMPS →	+0.841	+0.618	<.001	<.001	3	8
LSCC	CCDC58 →	+1.000	+0.632	<.001	<.001	3	8
HNSC	MSL2 →	+0.750	+0.340	<.001	<.001	3	8
UCEC	E2F1 →	+1.141	+0.260	.001	.003	3	7
GBM	BRIP1 →	+0.898	+0.299	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,991 associations by consensus.

Exploration

HMCES survival (RNA) · tumor vs normal (RNA) · all HMCES data types