HMBS

Across TCGA patient cohorts, HMBS RNA expression is significantly associated with the RNA expression of many other genes, with 18,497 significant associations in total. ACC shows the largest number of these associations.

The most reproducible HMBS-associated genes across cancer lineages are MRM1, MRPL12, and TIMM8B. Each is linked with HMBS in more than 31 cancer types. Because this analysis shows association rather than direction, both HMBS-to-partner and partner-to-HMBS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMBS versus MRM1 in ACC, with a Pearson correlation of 0.61.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBS→partner) and Y-score (partner→HMBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	MRM1 →	+0.860	+0.711	<.001	<.001	3	32
THYM	MRPL12 →	+0.970	+0.444	<.001	<.001	3	32
ACC	TIMM8B →	+1.220	+1.224	<.001	<.001	3	32
ACC	OTUB1 →	+1.009	+1.077	<.001	<.001	3	32
ACC	TMEM223 →	+1.275	+1.267	<.001	<.001	3	32
ACC	ARMC6 →	+0.786	+0.859	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,497 associations by consensus.

HMBS vs MRM1 — ACC

Explore this scatter interactively →