HMBS

Across TCGA patient cohorts, HMBS protein abundance is significantly associated with the RNA expression of many other genes, with 5,237 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMBS-associated genes across cancer lineages are STT3A, CWC15, and NKAPD1. Each is linked with HMBS in more than 4 cancer types. Because this analysis shows association rather than direction, both HMBS-to-partner and partner-to-HMBS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMBS versus STT3A in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBS→partner) and Y-score (partner→HMBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STT3A →	+0.504	+0.250	<.001	.001	3	5
OV	CWC15 →	+0.438	+0.308	.002	.005	3	4
BRCA	NKAPD1 →	+0.411	+0.300	<.001	<.001	3	4
HNSC	RNF26 →	+0.593	+0.302	.005	<.001	3	4
OV	USP28 →	+0.552	+0.350	.003	.002	3	4
LSCC	HBA2 →	+1.638	+0.326	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,237 associations by consensus.

HMBS vs STT3A — BRCA

Explore this scatter interactively →