HMBS

Across TCGA patient cohorts, HMBS mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMBS-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Caspase-7-cleavedD198. Each is linked with HMBS in more than 1 cancer types. Because this analysis shows association rather than direction, both HMBS-to-partner and partner-to-HMBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HMBS-low versus HMBS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBS→partner) and Y-score (partner→HMBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.191	-1.415	.042	.046	3	2
UCEC	MEK1 →	+0.422	+2.662	.002	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.627	+1.874	.004	.049	3	2
UCEC	C-Raf →	+0.178	+2.321	<.001	.033	3	2
UCEC	Cyclin-E2 →	+0.152	+1.710	.016	.025	3	2
UCEC	eIF4E →	+0.290	+2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by HMBS expression — UCEC

Explore this box plot interactively →