HMBS

Across TCGA cell cohorts, HMBS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,680 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HMBS-associated GO terms across cancer lineages are Ether catabolic process, Glycerol ether catabolic process, and Platelet activating factor catabolic process. Each is linked with HMBS in more than 13 cancer types. Because this analysis shows association rather than direction, both HMBS-to-partner and partner-to-HMBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ether catabolic process grouped by HMBS-low versus HMBS-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMBS→partner) and Y-score (partner→HMBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Ether catabolic process →	+0.246	+1.048	<.001	<.001	3	14
BLOOD_Myeloma	Glycerol ether catabolic process →	+0.246	+1.048	<.001	<.001	3	14
BLOOD_Myeloma	Platelet activating factor catabolic process →	+0.246	+1.048	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic metaphase chromosome alignment →	+0.108	+0.811	.004	.007	3	14
PANCREAS	Pyruvate decarboxylation to acetyl-CoA →	+0.201	+0.826	<.001	<.001	3	13
OVARY	mRNA modification →	+0.096	+0.830	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

Ether catabolic process by HMBS expression — BLOOD_Myeloma

Explore this box plot interactively →