HM13

Across TCGA cell cohorts, HM13 mutation is significantly associated with the mutation status of many other genes, with 2,455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HM13-associated genes across cancer lineages are ZNF337, DDX10, and PLCG2. Each is linked with HM13 in more than 2 cancer types. Because this analysis shows association rather than direction, both HM13-to-partner and partner-to-HM13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF337 grouped by HM13-low versus HM13-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HM13→partner) and Y-score (partner→HM13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF337 →	+4.807	+4.807	.008	.008	1	3
BLOOD_Leukemia	DDX10 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	PLCG2 →	+4.000	+5.050	.008	.008	1	3
LARGE_INTESTINE	HNRNPA1L2 →	+5.087	+4.523	.006	.006	1	3
UPPER_AERODIGESTIVE_TRACT	MYRIP →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	KPNA2 →	+5.392	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,455 associations by consensus.

ZNF337 by HM13 expression — STOMACH

Explore this box plot interactively →