HM13-IT1

Across TCGA pan-cancer cohorts, HM13-IT1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HM13-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HM13-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HM13-IT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

KIRC, KIRP, and UVM are the cancer types where HM13-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.537	0.721	<.001	93	view →
KIRP	DFS	Quartile	III,IV	0.182	0.741	.001	54	view →
UVM	DFS	Quartile	All	0.217	1.000	.001	37	view →
ACC	DFS	Median	III,IV	0.083	0.611	<.001	30	view →
UCEC	DFS	Quartile	All	0.532	0.787	.005	28	view →
THCA	DFS	Tertile	III,IV	0.831	0.954	.006	27	view →
SKCM	DFS	Median	All	0.250	0.158	.006	22	view →
LIHC	DFS	Quartile	All	0.436	0.577	.017	20	view →
LGG	DFS	Tertile	All	0.744	0.899	<.001	19	view →
READ	OS	Median	II,III,IV	0.775	0.462	.009	16	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	15	view →
KICH	DFS	Median	II,III,IV	0.634	1.000	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HM13-IT1–KIRC (OS)

Open the KIRC breakdown →