HM13-IT1

Across TCGA pan-cancer cohorts, HM13-IT1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HM13-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HM13-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HM13-IT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where HM13-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HM13-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.891	<.001	11	view →
HNSC	All	III,IV	+0.584	<.001	11	view →
COAD	Male	II,III,IV	+1.167	<.001	10	view →
STAD	All	All	+0.779	<.001	6	view →
BLCA	All	All	+0.629	.005	6	view →
LUAD	Female	All	+0.622	<.001	5	view →
LUSC	Male	All	+0.654	<.001	4	view →
BRCA	All	All	+0.334	.001	4	view →
THCA	All	All	−0.311	.011	4	view →
LIHC	All	All	+0.278	.002	4	view →
CHOL	All	All	+1.665	<.001	3	view →
READ	Female	All	+1.389	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HM13-IT1–KIRC

Open the KIRC breakdown →