HM13-AS1

Across TCGA pan-cancer cohorts, HM13-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HM13-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HM13-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HM13-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where HM13-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HM13-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.147	<.001	11	view →
KICH	All	All	−0.671	<.001	7	view →
LUAD	Female	II,III,IV	−0.551	<.001	7	view →
LUSC	All	III,IV	−0.698	.001	3	view →
HNSC	Male	III,IV	+0.389	.017	3	view →
CHOL	All	All	−0.676	.011	2	view →
KIRP	All	IV	+0.600	.044	2	view →
PRAD	All	All	−0.323	<.001	2	view →
BRCA	All	All	−0.099	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HM13-AS1–THCA

Open the THCA breakdown →