HLX

Across TCGA cell cohorts, HLX mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible HLX-associated genes across cancer lineages are IL22, LCE2B, and OR5B12. Each is linked with HLX in more than 1 cancer types. Because this analysis shows association rather than direction, both HLX-to-partner and partner-to-HLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by HLX-low versus HLX-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLX→partner) and Y-score (partner→HLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	1
STOMACH	LCE2B →	+0.205	+4.285	<.001	.007	3	1
STOMACH	OR5B12 →	+0.032	+5.247	<.001	<.001	3	1
STOMACH	CCDC197 →	+0.039	+4.129	<.001	.007	3	1
STOMACH	LCE2C →	+0.794	+4.285	<.001	.007	3	1
STOMACH	LCE2D →	+0.110	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

IL22 by HLX expression — STOMACH

Explore this box plot interactively →