HLX-AS1

Across TCGA pan-cancer cohorts, HLX-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HLX-AS1 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher HLX-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLX-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUAD show a favorable association.

ESCA, LUAD, and KIRC are the cancer types where HLX-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.634	0.368	.002	51	view →
LUAD	OS	Quartile	All	0.532	0.288	.001	46	view →
KIRC	DFS	Quartile	All	0.874	0.674	.006	37	view →
LUSC	OS	Quartile	III,IV	0.346	0.914	.009	36	view →
HNSC	DFS	Tertile	IV	0.441	0.265	.005	35	view →
THCA	DFS	Median	II,III,IV	0.792	0.926	.008	34	view →
UVM	OS	Median	All	0.767	1.000	.011	30	view →
MESO	OS	Quartile	All	0.255	0.710	.006	30	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	25	view →
KIRP	OS	Quartile	All	0.804	0.923	.008	24	view →
LIHC	OS	Median	II,III,IV	0.793	0.585	.004	19	view →
BLCA	DFS	Tertile	II,III,IV	0.224	0.408	.028	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HLX-AS1–ESCA (OS)

Open the ESCA breakdown →