HLX-AS1

Across TCGA pan-cancer cohorts, HLX-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HLX-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HLX-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HLX-AS1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and THCA are the cancer types where HLX-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLX-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.343	<.001	12	view →
LUSC	All	III,IV	−1.348	<.001	9	view →
THCA	All	II,III,IV	−0.357	<.001	9	view →
LUAD	Female	III,IV	−1.210	<.001	8	view →
BLCA	All	All	−0.605	.005	8	view →
KICH	Male	All	−0.513	<.001	8	view →
UCEC	All	All	−0.598	<.001	6	view →
BRCA	All	III,IV	−0.591	<.001	6	view →
READ	All	II,III,IV	−0.620	.007	4	view →
KIRP	All	All	−0.228	.001	3	view →
KIRC	Male	All	+0.191	.003	3	view →
HNSC	Male	All	−0.226	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HLX-AS1–COAD

Open the COAD breakdown →