HLTF-AS1

Across TCGA pan-cancer cohorts, HLTF-AS1 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated HLTF-AS1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher HLTF-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HLTF-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

OV, SKCM, and LIHC are the cancer types where HLTF-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	III,IV	0.337	0.140	.005	108	view →
SKCM	OS	Tertile	All	0.439	0.792	<.001	93	view →
LIHC	OS	Tertile	All	0.447	0.783	<.001	81	view →
KIRC	OS	Tertile	All	0.497	0.654	.005	40	view →
PCPG	DFS	Tertile	All	0.086	0.768	.007	18	view →
LGG	DFS	Tertile	All	0.511	0.746	.044	15	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
GBM	DFS	Tertile	All	0.145	0.306	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HLTF-AS1–OV (DFS)

Open the OV breakdown →