HLCS

Across TCGA patient cohorts, HLCS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,727 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLCS-associated proteins across cancer lineages are APP, ICAM3, and IRF4. Each is linked with HLCS in more than 4 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLCS versus APP in LSCC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APP →	+0.441	+0.393	<.001	.002	3	5
UCEC	ICAM3 →	-0.697	-0.439	.003	.002	3	4
BRCA	IRF4 →	-0.889	-0.626	<.001	<.001	3	4
BRCA	ISG20 →	-0.576	-0.447	<.001	<.001	3	4
LUAD	ANP32E →	+0.409	+0.368	.005	.001	3	4
LSCC	NAGK_S76 →	-0.298	-0.426	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,727 associations by consensus.

HLCS vs APP — LSCC

Explore this scatter interactively →