HLCS

Across TCGA patient cohorts, HLCS mutation is significantly associated with the RNA expression of many other genes, with 5,094 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLCS-associated genes across cancer lineages are MIR6803, RPLP1P10, and TYW5. Each is linked with HLCS in more than 2 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by HLCS-low versus HLCS-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR6803 →	+0.355	+4.798	<.001	.006	3	3
HNSC	RPLP1P10 →	+0.117	+5.505	<.001	.004	3	3
UCEC	TYW5 →	+0.309	+2.157	<.001	<.001	3	3
UCEC	SUGT1 →	+0.406	+2.807	<.001	<.001	3	3
BLCA	RN7SKP46 →	+0.090	+4.307	<.001	.005	3	2
UCEC	DDX52 →	+0.427	+1.928	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,094 associations by consensus.

MIR6803 by HLCS expression — STAD

Explore this box plot interactively →