HLCS

Across TCGA patient cohorts, HLCS mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLCS-associated genes across cancer lineages are p38-MAPK_pT180_Y182, FOXO3a, and MEK1_p_S217_S221. Each is linked with HLCS in more than 1 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by HLCS-low versus HLCS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.413	-2.415	.005	.003	3	2
SKCM	FOXO3a →	-0.122	-3.000	.022	.034	3	1
SKCM	MEK1_p_S217_S221 →	+0.298	+2.334	.006	.018	3	1
SKCM	Rictor_pT1135 →	+0.148	+1.891	.038	.030	3	1
SKCM	Src_pY416 →	+0.285	+3.459	.045	.005	3	1
SKCM	Collagen-VI →	+0.356	+2.584	.025	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p38-MAPK_pT180_Y182 by HLCS expression — UCEC

Explore this box plot interactively →