HLCS

Across TCGA cell cohorts, HLCS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,342 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HLCS-associated GO terms across cancer lineages are Biotin metabolic process, Cytosolic transport, and Peptidyl-serine phosphorylation. Each is linked with HLCS in more than 17 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Biotin metabolic process grouped by HLCS-low versus HLCS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Biotin metabolic process →	+0.186	+1.512	<.001	<.001	3	18
OESOPHAGUS	Cytosolic transport →	+0.073	+1.075	<.001	<.001	3	16
KIDNEY	Peptidyl-serine phosphorylation →	+0.087	+0.899	.001	<.001	3	15
PANCREAS	Cellular response to starvation →	+0.052	+1.101	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.121	-0.879	<.001	<.001	3	14
PANCREAS	Peptidyl-serine modification →	+0.084	+1.064	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,342 associations by consensus.

Biotin metabolic process by HLCS expression — OESOPHAGUS

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