HLCS-IT1

Across TCGA patient cohorts, HLCS-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,496 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLCS-IT1-associated proteins across cancer lineages are ANP32E, SON, and SCAF4. Each is linked with HLCS-IT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HLCS-IT1-to-partner and partner-to-HLCS-IT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLCS-IT1 versus ANP32E in LSCC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS-IT1→partner) and Y-score (partner→HLCS-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANP32E →	+0.330	+0.489	.002	<.001	3	4
GBM	SON →	+0.190	+0.365	<.001	<.001	3	4
LSCC	SCAF4 →	+0.238	+0.432	<.001	<.001	3	4
LSCC	PAXBP1 →	+0.270	+0.617	<.001	<.001	3	4
GBM	UTP18_S205 →	+0.462	+0.379	.005	.007	3	3
LSCC	FAM169A_S619 →	+0.648	+0.703	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,496 associations by consensus.

HLCS-IT1 vs ANP32E — LSCC

Explore this scatter interactively →