HLCS-IT1

Across TCGA pan-cancer cohorts, HLCS-IT1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HLCS-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HLCS-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HLCS-IT1 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

KIRC, ACC, and UVM are the cancer types where HLCS-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.473	0.687	<.001	120	view →
ACC	OS	Quartile	All	0.386	0.700	<.001	70	view →
UVM	OS	Tertile	All	0.037	0.835	<.001	54	view →
LGG	DFS	Tertile	All	0.250	0.430	<.001	34	view →
OV	OS	Tertile	II,III,IV	0.896	0.808	.014	32	view →
MESO	OS	Median	III,IV	0.276	0.470	.003	27	view →
THCA	DFS	Quartile	III,IV	0.656	0.861	.006	24	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	18	view →
ESCA	DFS	Median	II,III,IV	0.418	0.620	.003	15	view →
LIHC	DFS	Quartile	III,IV	0.157	0.375	.005	15	view →
READ	DFS	Tertile	IV	0.112	0.811	.008	14	view →
UCEC	OS	Quartile	III,IV	0.823	0.599	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HLCS-IT1–KIRC (OS)

Open the KIRC breakdown →