Across TCGA patient cohorts, HLA-S RNA expression is significantly associated with the go_rna of many other GO terms, with 6,617 significant associations in total. LGG shows the largest number of these associations.

The most reproducible HLA-S-associated GO terms across cancer lineages are Positive regulation of regulatory T cell differentiation, Antigen processing and presentation of endogenous peptide antigen, and Positive regulation of tolerance induction. Each is linked with HLA-S in more than 25 cancer types. Because this analysis shows association rather than direction, both HLA-S-to-partner and partner-to-HLA-S results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-S→partner) and Y-score (partner→HLA-S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Positive regulation of regulatory T cell differentiation →	+0.066	+1.745	<.001	<.001	3	26
ACC	Antigen processing and presentation of endogenous peptide antigen →	+0.068	+1.082	<.001	<.001	3	26
ESCA	Positive regulation of tolerance induction →	+0.094	+0.854	<.001	<.001	3	25
LAML	Positive regulation of T cell tolerance induction →	+0.085	+0.720	<.001	<.001	2	26
ESCA	Regulatory T cell differentiation →	+0.064	+0.916	<.001	<.001	3	25
ESCA	Type II interferon-mediated signaling pathway →	+0.097	+1.061	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,617 associations by consensus.

Exploration

HLA-S survival (RNA) · tumor vs normal (RNA) · all HLA-S data types