Across TCGA pan-cancer cohorts, HLA-S RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HLA-S data layer.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-S RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-S expression acts as an unfavorable survival marker, although some lineages such as SKCM and LIHC show a favorable association.
SKCM, LIHC, and BLCA are the cancer types where HLA-S RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.