HLA-P

Across TCGA patient cohorts, HLA-P RNA expression is significantly associated with the go_rna of many other GO terms, with 6,867 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HLA-P-associated GO terms across cancer lineages are Antigen processing and presentation of endogenous peptide antigen, Positive regulation of T cell mediated cytotoxicity, and Antigen processing and presentation of peptide antigen via MHC class I. Each is linked with HLA-P in more than 22 cancer types. Because this analysis shows association rather than direction, both HLA-P-to-partner and partner-to-HLA-P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of endogenous peptide antigen grouped by HLA-P-low versus HLA-P-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-P→partner) and Y-score (partner→HLA-P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Antigen processing and presentation of endogenous peptide antigen →	+0.078	+0.345	<.001	<.001	3	23
CHOL	Positive regulation of T cell mediated cytotoxicity →	+0.058	+0.291	<.001	.001	3	22
CHOL	Antigen processing and presentation of peptide antigen via MHC class I →	+0.055	+0.284	<.001	<.001	3	22
STAD	Dendritic cell differentiation →	+0.056	+0.124	<.001	<.001	3	21
ESCA	Response to type II interferon →	+0.060	+0.111	<.001	<.001	3	21
ESCA	Regulatory T cell differentiation →	+0.051	+0.089	.001	.005	1	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,867 associations by consensus.

Antigen processing and presentation of endogenous peptide antigen by HLA-P expression — CHOL

Explore this box plot interactively →