HLA-P

Across TCGA pan-cancer cohorts, HLA-P RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HLA-P data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HLA-P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HLA-P expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

CESC, SKCM, and MESO are the cancer types where HLA-P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.606	0.261	.001	138	view →
SKCM	DFS	Median	II,III,IV	0.649	0.498	<.001	67	view →
MESO	DFS	Median	All	0.494	0.301	.005	43	view →
LGG	DFS	Median	All	0.640	0.789	<.001	41	view →
UCEC	DFS	Median	All	0.863	0.926	.001	20	view →
KIRC	DFS	Quartile	All	0.924	0.837	.023	12	view →
LUSC	DFS	Median	All	0.327	0.437	.020	11	view →
THYM	OS	Quartile	All	0.618	0.982	.002	10	view →
UVM	DFS	Median	II,III,IV	0.615	0.838	.011	10	view →
GBM	DFS	Tertile	All	0.196	0.303	.028	9	view →
PCPG	DFS	Quartile	All	0.607	0.967	.009	9	view →
COAD	OS	Median	III,IV	0.878	0.699	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HLA-P–CESC (DFS)

Open the CESC breakdown →