Across TCGA pan-cancer cohorts, HLA-N RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HLA-N’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HLA-N RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-N is over-expressed in tumor.

COAD are the cancer types where HLA-N tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-N RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.236	.011	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: HLA-N RNA expression & survival · all HLA-N data types