HLA-L

Across TCGA patient cohorts, HLA-L RNA expression is significantly associated with the protein abundance of many other proteins, with 9,746 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-L-associated proteins across cancer lineages are TAP1, TAPBP, and ANKRD44. Each is linked with HLA-L in more than 5 cancer types. Because this analysis shows association rather than direction, both HLA-L-to-partner and partner-to-HLA-L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-L versus TAP1 in OV, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-L→partner) and Y-score (partner→HLA-L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TAP1 →	+0.727	+1.025	<.001	<.001	3	6
OV	TAPBP →	+0.458	+0.765	<.001	<.001	3	6
OV	ANKRD44 →	+0.406	+0.632	<.001	.002	3	6
LSCC	DOCK10 →	+0.394	+0.386	<.001	.003	3	6
OV	TRAF1 →	+1.017	+0.733	.002	.001	3	5
OV	TRIM38 →	+0.409	+0.805	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,746 associations by consensus.

HLA-L vs TAP1 — OV

Explore this scatter interactively →