HLA-L

Across TCGA pan-cancer cohorts, HLA-L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HLA-L data layer.

The strongest signal is observed in mesothelioma (MESO), where higher HLA-L RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-L expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

MESO, SKCM, and LGG are the cancer types where HLA-L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.715	0.412	<.001	69	view →
SKCM	OS	Quartile	II,III,IV	0.517	0.246	<.001	55	view →
LGG	OS	Median	All	0.749	0.869	<.001	48	view →
UCEC	DFS	Tertile	All	0.711	0.548	.001	46	view →
UVM	DFS	Median	III,IV	0.302	0.889	.007	26	view →
KIRC	DFS	Quartile	All	0.752	0.430	.004	20	view →
READ	OS	Median	All	1.000	0.805	.002	19	view →
ACC	DFS	Tertile	IV	0.594	0.160	.019	15	view →
LIHC	DFS	Median	II,III,IV	0.323	0.151	.005	14	view →
PAAD	OS	Tertile	II,III,IV	0.746	0.499	.013	13	view →
STAD	DFS	Tertile	IV	0.102	0.501	.031	9	view →
GBM	DFS	Tertile	All	0.156	0.251	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HLA-L–MESO (OS)

Open the MESO breakdown →