HLA-K

Across TCGA patient cohorts, HLA-K RNA expression is significantly associated with the go_rna of many other GO terms, with 7,145 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible HLA-K-associated GO terms across cancer lineages are Negative regulation of innate immune response, MDA-5 signaling pathway, and Positive regulation of pattern recognition receptor signaling pathway. Each is linked with HLA-K in more than 23 cancer types. Because this analysis shows association rather than direction, both HLA-K-to-partner and partner-to-HLA-K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of innate immune response grouped by HLA-K-low versus HLA-K-high in SKCM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-K→partner) and Y-score (partner→HLA-K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Negative regulation of innate immune response →	+0.044	+0.861	<.001	<.001	3	24
SKCM	MDA-5 signaling pathway →	+0.066	+0.734	<.001	<.001	3	23
LAML	Positive regulation of pattern recognition receptor signaling pathway →	+0.046	+0.683	<.001	<.001	3	22
LAML	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.037	+0.712	<.001	<.001	3	22
SKCM	Tumor necrosis factor-mediated signaling pathway →	+0.036	+0.806	<.001	<.001	3	22
THYM	Canonical NF-kappaB signal transduction →	+0.028	+0.969	<.001	.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,145 associations by consensus.

Negative regulation of innate immune response by HLA-K expression — SKCM

Explore this box plot interactively →