Across TCGA cell cohorts, HLA-H protein abundance is significantly associated with the RNA expression of many other genes, with 2,559 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-H-associated genes across cancer lineages are HLA-B, TAP1, and HLA-C. Each is linked with HLA-H in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-H-to-partner and partner-to-HLA-H results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-H→partner) and Y-score (partner→HLA-H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HLA-B →	+4.640	+3.834	<.001	<.001	3	10
OESOPHAGUS	TAP1 →	+1.829	+2.922	.005	.006	3	9
OESOPHAGUS	HLA-C →	+1.896	+2.382	.001	<.001	3	8
BREAST	HLA-F →	+2.841	+1.956	<.001	.001	3	8
BLOOD_Lymphoma	HLA-A →	+2.591	+2.139	<.001	<.001	3	8
BREAST	NLRC5 →	+1.492	+2.341	.007	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,559 associations by consensus.

Exploration

HLA-H survival (RNA) · tumor vs normal (RNA) · all HLA-H data types