Across TCGA patient cohorts, HLA-F-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,495 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HLA-F-AS1-associated proteins across cancer lineages are TRIM47, PSMB5, and ICAM1. Each is linked with HLA-F-AS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HLA-F-AS1-to-partner and partner-to-HLA-F-AS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-F-AS1→partner) and Y-score (partner→HLA-F-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM47 →	+0.407	+0.765	<.001	<.001	3	6
LUAD	PSMB5 →	-0.427	-0.631	<.001	<.001	3	6
LUAD	ICAM1 →	+0.635	+0.674	<.001	.002	3	5
UCEC	EHD1 →	+0.390	+0.778	<.001	<.001	3	5
UCEC	DPYD →	+0.391	+0.468	<.001	<.001	3	5
PDAC	TBRG4 →	-0.365	-0.504	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,495 associations by consensus.

Exploration

HLA-F-AS1 survival (RNA) · tumor vs normal (RNA) · all HLA-F-AS1 data types