Across TCGA patient cohorts, HLA-E mutation is significantly associated with the RNA expression of many other genes, with 795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-E-associated genes across cancer lineages are MIR98, MTND2P25, and RNU6-929P. Each is linked with HLA-E in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-E-to-partner and partner-to-HLA-E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-E→partner) and Y-score (partner→HLA-E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR98 →	+0.406	+2.631	<.001	.007	3	2
HNSC	MTND2P25 →	+0.099	+7.954	<.001	.008	3	2
COAD	RNU6-929P →	+0.323	+7.741	<.001	.009	3	2
UCEC	RNU4-58P →	+0.234	+2.963	.001	.003	3	2
UCEC	LINC00899 →	+0.635	+3.483	<.001	.002	3	2
UCEC	RNA5SP423 →	+0.956	+2.939	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 795 associations by consensus.

Exploration

HLA-E survival (RNA) · tumor vs normal (RNA) · all HLA-E data types